MOLECULAR NETWORK ANALYSIS SUGGESTS A LOGICAL HYPOTHESIS FOR THE PATHOLOGICAL ROLE OF C9ORF72 IN AMYOTROPHIC LATERAL SCLEROSIS/FRONTOTEMPORAL DEMENTIA

Background Expanded GGGGCC hexanucleotide repeats, ranging from hundreds to thousands in number, located in the noncoding region of the chromosome 9 open reading frame 72 ( C9orf72 ) gene represent the most common genetic abnormality for familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (abbreviated as C9AL

This paper discusses the implementation of five key strategies of reducing dwelling time at ports.The five strategies are deregulation of administrative procedures, availability of infrastructure and port facilities, integration of information technology, quality of services, price and Speaker Accessories incentive strategies.By using partial least

Huangjiu is the oldest Silicone Mat fermented alcoholic drink in China, earning the reputation as the "national alcoholic drink".Fangxian, located in Shiyan, the core water source area of the South-to-North Water Diversion Project, is the most important area of Huangjiu production.In recent years, the Shiyan municipal Party Committee and

Patients with a missing tooth along with diastema have limited treatment options to restore the edentulous space.The use of a conventional fixed partial denture (FPD) to replace the missing tooth may result in too wide anterior teeth leading to poor esthetics.Loss of anterior teeth with existing diastema may result concave roller in excess space av

Abstract Background To compare the dosimetric advantage of three different intensity-modulated Entertainment Unit radiation therapy (IMRT) plans to a three dimensional (3D) conventional radiation treatment for anal cancer with regards to organs-at-risk (OAR) avoidance, including iliac bone marrow.Methods Five patients with T1-3 N0-1 anal cancer and